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These AHLs are made by enzymes known as Luxl homologs, and accumulate in the culture supernatant at a rate proportional to the increase in cell density. The best characterized mechanisms of QS employ N-acylated homoserine lac tones (AHLs) as signalling molecules. The role of QS is to enable the cells in a culture to coordinate their gene expression profile with changes in the population cell density. Many Gram-negative bacteria employ a mechanism of cell-cell communication known as quorum sensing (QS).
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